OXOLINIC ACID IMPURITY A - Names and Identifiers
OXOLINIC ACID IMPURITY A - Physico-chemical Properties
| Molecular Formula | C11H7NO5
|
| Molar Mass | 233.18 |
| Density | 1.678±0.06 g/cm3(Predicted) |
| Melting Point | >290 °C(Solv: N,N-dimethylformamide (68-12-2)) |
| Boling Point | 459.2±45.0 °C(Predicted) |
| Appearance | neat |
| pKa | 0.85±0.20(Predicted) |
OXOLINIC ACID IMPURITY A - References
| quinolinone bactericide | , it is white with yellow-white columnar crystal or crystalline powder at room temperature, odorless and tasteless, has strong antibacterial effect on Gram-negative bacteria and some positive bacteria, and has no cross resistance to antibiotics, but it has no antibacterial effect on fungi and Mycobacterium tuberculosis, and has the advantages of low dosage and good antibacterial effect. It is mainly used for the treatment of bacterial diseases of fish and shrimp, it is considered to be one of the ideal drugs for the treatment of aquatic animal diseases, and has a strong antibacterial activity against Vibrio anguillarum, Aeromonas hydrophila and other fish pathogens. So the eel and other aquatic animals are widely used in Japan and Taiwan province, and the PH has a slight effect on it in the marine culture, and the dosage of the drug should be increased in alkaline environment. Oxolinic acid has little toxicity, acute, toxicity test of carp oral median lethal dose (I. E. Under the influence of a certain concentration of the drug can make 50% of the time of individual death) for 4000mg/kg or more. And the use of the drug must be stopped before 25 days, otherwise excessive residues, the Japanese market banned imports, Taiwan increased Oxolinic acid (Oxolinic acid) in fish, shrimp, eggs, cattle, pigs, chicken muscle, fat, liver and kidney of the thirteen items of residue tolerance.
there is an evolutionary process in the use of drugs for eel in various countries, In September 1991, the Japanese international veterinary epidemic affairs bureau held a special meeting to discuss the use standards of aquatic medicine for Japanese eel and the chemotherapy of aquaculture, involving therapy, drug toxicity, drug resistance, residues and other issues, the general trend is: the increase of fish disease species, the increase of therapeutic drugs, the increase of residual drugs in the environment is a new important problem facing the aquaculture interface, japan revised the standard for the use of aquatic drugs three times from 1991 to 1992, and promulgated the "standard" for the use of drugs in eel water, which lists the names of drugs that can be used and drugs that cannot be used and the methods of use. Although the oxolinic acid is included in the range of drugs that can be used within the standard of use, and the oxolinic acid is prescribed for a period of 25 days, 20 mg/kg of fish/day, oral and medicinal solvent 5ppm to maintain the provisions of 6 hours, but China's food and livestock import and export chamber of commerce in order to make China's export eel breeding scientific, its products meet the food hygiene requirements of the importing country, to enhance the confidence of the importer to buy the eel in China, and stabilize the export market, the article was issued on the 28th of 4.9, 1989, and promulgated the health management and medication management (interim) measures for the export of eel in China. Oxolinic acid, malachite green and methyl blue are prohibited drugs.
Last Update：2024-04-09 21:04:16
